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Direct sequencing confirmed that every positive sample in the screening methods had a variation in the DNA sequence. The SNP was detected in 52 out of 175 patients (30 %), both by HRM and hybridization probes. Direct sequencing was used to validate both techniques. One hundred and seventy-five adult de novo AML patients were screened with two different methods for the detection of SNP rs16754: high-resolution melting (HRM) and FRET hybridization probes. Nevertheless, the findings in this field are not always reproducible in different series. The single nucleotide polymorphism ( SNP) rs16754 of the WT 1 gene has been previously described as a possible prognostic marker in normal karyotype acute myeloid leukemia (AML) patients. Luna, Irene Such, Esperanza Cervera, Jose Barragán, Eva Jiménez-Velasco, Antonio Dolz, Sandra Ibáñez, Mariam Gómez-SeguÃ, Inés López-PavÃa, MarÃa Llop, Marta Fuster, Óscar Oltra, Silvestre Moscardó, Federico MartÃnez-Cuadrón, David Senent, M Leonor Gascón, Adriana Montesinos, Pau MartÃn, Guillermo Bolufer, Pascual Sanz, Miguel A Analysis of SNP rs16754 of WT 1 gene in a series of de novo acute myeloid leukemia patients.
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